A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
3D Ex vivo tissue platforms to investigate the early phases of influenza a virus- and SARS-CoV-2-induced respiratory diseasesArticle Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 신약개발, 진단, 치료제, [키워드] animal model animal models Antiviral Cell Cell culture comparable consequence Drug repurposing drug target early phase Ex vivo ex vivo infection Ex vivo infection model Health Host human lung IAV in vitro Infection Inflammatory cytokine Influenza influenza A virus Influenza virus Innate immunity innate immunity. interferon interferon response Intervention introduced lung tissue morbidity and mortality murine outbreak pathophysiological pharmacological platform Respiratory disease respiratory viruses responses SARS-CoV-2 therapy tissue Treatment viral infection viral life cycle viral replication virus virus while [DOI] 10.1080/22221751.2022.2117101 PMC 바로가기
Autophagy-linked plasma and lysosomal membrane protein PLAC8 is a key host factor for SARS-CoV-2 entry into human cellsArticle Published on 2022-11-022022-11-15 Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 진단, [키워드] Affect analyses autophagy Better boost cancer cell cancer cell lines Cell cell type ciliated conducted COVID-19 pathology COVID19 Critical eight endocytosed enterocytes experiment expressed Factor Genetic genetic screen Gut help Host host cell human cell human lung identify impair Infection Interaction lentiviruses loss-of-function lysosomal lysosomal membrane overexpression plac8 plasma Protein regulate respiratory tract SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 virus SARS-CoV-2 viruses secretory cell single-cell SPNS1 spns1. susceptible viral entry viral infection virions [DOI] 10.15252/embj.2022110727 PMC 바로가기
Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cellsArticle Published on 2022-11-022022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Antiviral antivirals approved drug caused clinical evaluation Combination Compound concentrations conducted COVID-19 drug Effect Efficacy epithelial cell line exonuclease global pandemic HCV hepatitis C human lung human lung cell identify inhibitor moderate morbidity Mortality NS5A pharmacokinetic profiles Protein Remdesivir SARS Coronavirus SARS-CoV-2 SARS-CoV-2 replication Support synergy the SARS-CoV-2 therapeutic treatment strategy virus [DOI] 10.1038/s41598-022-21034-5 PMC 바로가기
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitroArticle Published on 2022-11-012022-11-15 Journal: Virus research [Category] SARS, 치료법, 치료제, [키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while [DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기
SARS-CoV-2 Omicron variant is attenuated for replication in a polarized human lung epithelial cell modelArticle Published on 2022-10-272022-11-16 Journal: Communications Biology [Category] COVID19(2023년), SARS, 변종, [키워드] Air-liquid interface Analysis assessment Cell Culture D614G Delta Epidemic epidemiological epithelial Health human coronavirus human lung immortalized Infection Lower respiratory tract omicron pathogenicity reduced Replication respiratory virus risk SARS-CoV-2 Seasonal influenza significantly variant variants variants of concern virus virus infection [DOI] 10.1038/s42003-022-04068-3 PMC 바로가기
LRRC15 inhibits SARS-CoV-2 cellular entry in transArticle Published on 2022-10-132022-11-16 Journal: PLoS Biology [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 Activation angiotensin-converting enzyme 2 bind block Cell cell type cellular entry coexpressed coronavirus 2 COVID-19 patients CRISPR dataset entry receptor expression Factor fibroblast human lung Infection inhibit inhibiting inhibitory LRRC15 lung moderate physiological protective role RBD regulate respiratory reveal SARS-CoV-2 SARS-CoV-2 entry Single-cell RNA sequencing Spike protein the receptor-binding domain viral entry [DOI] 10.1371/journal.pbio.3001805 PMC 바로가기
Nafamostat Mesylate for Treatment of COVID-19 in Hospitalised Patients: A Structured, Narrative ReviewArticle Published on 2022-10-012022-11-15 Journal: Clinical pharmacokinetics [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome addition Antithrombotic Antiviral antiviral potency benefit cell line cellular clinical Clinical outcome clinical study clinical trial clinically Coronavirus-2 COVID-19 disease Disseminated intravascular coagulation drug effective Efficacy enzyme human cells human lung hypothesised indication inhibitory concentration intravenous investigated Japan Laboratory mesylate nafamostat Nafamostat mesylate narrative patients with moderate pharmacokinetic protease recruitment Remdesivir repurposing review robust SARS-CoV-2 serine 2 severe COVID-19 TMPRSS2 transmembrane treatment for COVID-19 viral entry [DOI] 10.1007/s40262-022-01170-x PMC 바로가기
Humanized mice for investigating SARS-CoV-2 lung infection and associated human immune responsesArticle Published on 2022-10-012022-11-15 Journal: European Journal of Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome animal model anti-SARS-CoV-2 Anti-viral immune response associated immune response autologous chemotaxis coronavirus coronavirus disease Defense detectable Differentially expressed genes hemorrhage HISL mice human immune response Human immune system human lung humanized humanized mouse IFN Immune cell infiltration Immunopathogenesis immunopathology in viral in vivo model infected with SARS-CoV-2 infecting lack Live virus Lung infection lung infection. mice multiple organ NSG mice pulmonary fibrosis responses SARS-CoV-2 SARS-COV-2 infection Support susceptible therapeutic Therapies tissue Vero Cell [DOI] 10.1002/eji.202249804 PMC 바로가기
SARS-CoV-2 variants Alpha, Beta, Delta and Omicron show a slower host cell interferon response compared to an early pandemic variantArticle Published on 2022-09-302022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 치료제, [키워드] Activation analyzed antiviral response arising Beta Calu-3 cell calu-3 cells cellular circumvent comparable replication correlated COVID-19 infection Delta Effect epithelial Evolution genomic host cell human lung Immunity induce innate immune innate immune activation Innate immunity interferon interferon response ISG ISGs mRNA expression Mutation mutations omicron pandemic produced Replication replication efficiency SARS-CoV-2 SARS-CoV-2 variant signaling pathways STAT2 stimulated Transmission Treatment vaccination Vaccine variant variants variants of concern variants. variations Viral RNA virus virus replication while [DOI] 10.3389/fimmu.2022.1016108 PMC 바로가기